AIDS Certified Registered Nurse (ACRN) Certification Practice Test & Prep

Zidovudine is the antiretroviral drug associated with the potential side effect of myopathy. Myopathy refers to muscle weakness or pain, and it is an important consideration when managing patients on this medication. Zidovudine, which is a nucleoside reverse transcriptase inhibitor (NRTI), is known to cause two types of muscle-related side effects: myopathy and lactic acidosis. This is due to its mechanism of action, which interferes with cellular metabolism. Specifically, it can affect the muscles due to its impact on mitochondrial DNA, leading to muscle toxicity.

It is essential for healthcare providers to monitor patients on zidovudine for symptoms such as muscle pain or weakness, as early intervention may be necessary to manage this side effect effectively. Recognizing the potential for myopathy allows for better patient care and management decisions in the treatment of HIV/AIDS.